Table 5. Multivariable analysis to examine salivary taxa associated with high numbers of diseases and conditions previously linked to distinct oral microbiome profiles, among those with severe periodontal disease (n = 84).

	Taxa associated with numbers of diseases and conditions subjects with severe periodontitis (n = 84)
	Adjusted for caries, gender, age, tobacco use
	Taxa	Coef1	Std. Dev.	p-value	q-value
	Leptotrichia.s__sp._HMT_221	−0.9844	0.2444	0.0001	0.0060
	Gemella.s__morbillorum	−0.5162	0.1484	0.0005	0.0260
	Porphyromonas.s__gingivalis	−1.0355	0.3103	0.0008	0.0345
	Tannerella.s__forsythia	−0.6964	0.2083	0.0008	0.0345
	Corynebacterium.s__durum	−0.5959	0.1864	0.0014	0.0438
	Streptococcus.s__gordonii	−0.4589	0.1440	0.0014	0.0442
	g__Capnocytophaga.__	−0.4594	0.1446	0.0015	0.0442
	Actinomyces.s__sp._HMT_171	−0.9474	0.3007	0.0016	0.0442
	Capnocytophaga.s__granulosa	−0.6892	0.2189	0.0016	0.0442
	Leptotrichia.s__sp._HMT_212	−0.5345	0.1757	0.0024	0.0559
	Corynebacterium.s__matruchotii	−0.4558	0.1516	0.0026	0.0602
	Actinomyces.s__gerencseriae	0.5750	0.1966	0.0034	0.0702
	Desulfobulbus.s__sp._HMT_041	−1.5809	0.5538	0.0043	0.0819
	Actinomyces.s__graevenitzii	0.3961	0.1400	0.0047	0.0863
	g__Rothia.__	−0.5373	0.1945	0.0057	0.0953

Notes.

¹List of condition and disease (Table S3) is limited to those known to be associated with oral microbial taxa differences.

²Negative coefficient indicates taxa that decrease with high number of disease/conditions.

³Taxa with differential level of significance at False Discovery Rate of q < 0.1.