TABLE 3.
Multivariate analysis of initiating targeted therapy among mCRC (China, 2023).
| Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
| aOR (95% CI) | P | aOR (95% CI) | P | aOR (95% CI) | P | |
| Predisposing factors | ||||||
| Type of treating hospital | ||||||
| Cancer hospital | Reference | Reference | Reference | |||
| General hospital | 0.683 (0.562–0.830) | <0.001 | 0.608 (0.494–0.748) | <0.001 | 0.580 (0.466–0.721) | <0.001 |
| Age at mCRC diagnosis (years) | ||||||
| <65 | Reference | Reference | Reference | |||
| 65 | 0.681 (0.550–0.843) | <0.001 | 0.745 (0.597–0.931) | 0.010 | 0.780 (0.620–0.982) | 0.034 |
| Enabling factors | ||||||
| Educational level (years) | ||||||
| 0–6 | 0.703 (0.499–0.990) | 0.043 | 0.703 (0.494–0.999) | 0.049 | ||
| 7–12 | 0.978 (0.732–1.307) | 0.882 | 0.978 (0.726–1.317) | 0.882 | ||
| >12 | Reference | Reference | ||||
| Annual family income (CNY) | ||||||
| <50,000 | 0.674 (0.485–0.938) | 0.019 | 0.707 (0.501–0.996) | 0.049 | ||
| 50,000–99,999 | 0.698 (0.504–0.969) | 0.032 | 0.731 (0.522–1.022) | 0.067 | ||
| 100,000 | Reference | Reference | ||||
| Medical insurance | ||||||
| None | 0.191 (0.067–0.548) | 0.002 | 0.203 (0.069–0.593) | 0.004 | ||
| Private/Public | 0.753 (0.545–1.042) | 0.087 | 0.775 (0.555–1.082) | 0.135 | ||
| Private and Public | Reference | Reference | ||||
| Geographic region | ||||||
| East | 0.938 (0.663–1.328) | 0.719 | 0.986 (0.688–1.413) | 0.939 | ||
| North | 1.875 (1.187–2.961) | 0.007 | 1.992 (1.239–3.202) | 0.004 | ||
| South | 0.625 (0.416–0.938) | 0.023 | 0.733 (0.479–1.123) | 0.153 | ||
| Central | Reference | Reference | ||||
| Northeast | 0.896 (0.568–1.413) | 0.637 | 0.851 (0.532–1.362) | 0.502 | ||
| Southwest | 0.693 (0.482–0.995) | 0.047 | 0.684 (0.470–0.994) | 0.047 | ||
| Northwest | 0.553 (0.344–0.888) | 0.014 | 0.617 (0.237–0.997) | 0.043 | ||
| Need-for-care factors | ||||||
| HRQOL prior to the first mCRC treatment | ||||||
| Poor | 0.729 (0.586–0.907) | 0.005 | ||||
| Good | Reference | |||||
| Duration of mCRC (months) | ||||||
| <12 | 0.469 (0.382–0.576) | <0.001 | ||||
| 12 | Reference | |||||
| Metastatic site | ||||||
| Liver/lung | Reference | |||||
| Liver and lung | 1.614 (1.136–2.295) | 0.008 | ||||
| Outside liver/lung or systemic metastasis | 0.753 (0.606–0.936) | 0.011 | ||||
| AIC | 2308.36 | 2258.36 | 2178.60 | |||
The variables in the multivariate regression model were determined through step-wise method.
Model 1 included predisposing factors; Model 2 superimposed enabling factors on Model 1; Model 3 superimposed need-for-care factors on Model 2.
aOR, adjusted odds ratio; CI, confidence interval; CNY, Chinese Yuan; HRQOL, health-related quality of life; AIC, Akaike’s information criterion.