Table 3.

Selection of Case Reports on CNS Disorders Associated with Primary EBV-Infection Without IM Manifestation

Symptoms or Syndrome	Age (Years)	EBV in CSF (Copy No.)	Therapy	Outcome	Ref.
Meningoencephalitis	2	Positive	Corticosteroids	Complete remission	[126]
Encephalomyelitis and meningoradiculitis. Flaccid paraparesis, confusion.	23	Positive	Acyclovir	No immediate effect. Positive outcome.	[59]
Meningoencephalomyelitis	15	400 copies/mL	Acyclovir Ganciclovir Corticosteroids	Positive outcome	[58]
Encephalitis	21	Positive	Acyclovir Immunoglobulin	Good recovery	[127]
Encephalitis	8	Negative	Acyclovir Corticosteroids	Complete remission	[128]
Encephalitis, widespread encephalopathy	8	26,400 copies/mL	Gancyclovir Corticosteroids	Positive outcome	[129]
Acute cerebellar ataxia	42	7843 copies/mL	Supportive	Complete remission in two weeks	[130]
Acute cerebellar ataxia	38	ND	Acyclovir Immunoglobulin	Positive outcome	[73]
Acute cerebellar ataxia	23	Negative	Acyclovir Corticosteroids	Remission after dexamethasone. No residual deficit	[72]
Acute cerebellar ataxia	23	Negative	Immunoglobulin	Rapid resolution	[74]
Acute cerebellitis	37	Negative	Acyclovir Corticosteroids	Complete remission	[131]

Note: All cases presented with EBV serology suggestive of primary infection.