Table 1.
TNF superfamily members and receptors implicated in fibrosis.
| Ligand | TNFSF Nomenclature | Receptor | TNFRSF Nomenclature |
|---|---|---|---|
| TNF (TNFα) | TNFSF2 | TNFR1 (CD120a, TNFAR, p55) | TNFRSF1A |
| TNFR2 (CD120b, TNFBR, p75) | TNFRSF1B | ||
| LIGHT (CD258, HVEM-L) | TNFSF14 | HVEM (CD270, ATAR, TR2) | TNFRSF14 |
| LTβR (CD18, TNFCR) | TNFRSF3 | ||
| DcR3 (TR6, M68) | TNFRSF6B | ||
| TL1A (VEGI, TL1) | TNFSF15 | DR3 (Apo-3, TRAMP, LARD, WS-1) | TNFRSF25 |
| DcR3 (TR6, M68) | TNFRSF6B | ||
| APRIL (CD256, TALL-2) | TNFSF13 | TACI (CD267, IGAD2) | TNFRSF13B |
| BCMA (CD269) | TNFRSF13A | ||
| BAFF (CD257, BLyS, TALL-2) | TNFSF13B | TACI (CD267, IGAD2) | TNFRSF13B |
| BCMA (CD269, BCM) | TNFRSF13A | ||
| BAFFR (CD268) | TNFRSF13C | ||
| RANKL (CD254, TRANCE, OPGL, ODF) | TNFSF11 | RANK (CD265, ODFR, FEO) | TNFRSF11A |
| OPG (OCIF, TR1) | TNFRSF11B | ||
| GITRL (TL6, AITRL) | TNFSF18 | GITR (CD357, AITR) | TNFRSF18 |
| OX40L (CD252, CD134L, Gp34, TXGP1) | TNFSF4 | OX40 (CD134, ACT35, TXGP1L) | TNFRSF4 |
| CD70 (CD27L) | TNFSF7 | CD27 (S152, Tp55) | TNFRSF7 |
| TRAIL (CD253, APO-2L, TL2) | TNFSF10 | DR4 (CD261, TRAILR1, Apo-2) | TNFRSF10A |
| DR5 (CD262, TRAILR2, KILLER) | TNFRSF10B | ||
| DcR1 (CD263, TRAILR3, LIT, TRID) | TNFRSF10C | ||
| DcR2 (CD264, TRAILR4, TRUNDD) | TNFRSF10D |
TNFSF members and their corresponding receptors discussed in this review article. Common ligand and corresponding receptor names are listed in bold. Alternative ligand and receptor names are listed in parenthesis.