TABLE 2.
Clinical data at admission and death day of 13 YF patients analyzed in this study.
| GENERAL DATA | ID | P 1 | P 2 | P 3 | P 4 | P 5 | P 6 | P 7 | P 8 | P 9 | P 10 | P 11 | P 12 | P 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AGE | 24 | 54 | 62 | 45 | 41 | 80 | 55 | 55 | 64 | 27 | 46 | 56 | 68 | |
| SEX | male | male | male | male | male | male | male | male | male | male | male | male | male | |
| anti-YFV IgM (CSF) | reactive | reactive | NR | reactive | NR | reactive | reactive | reactive | reactive | NR | reactive | NR | n/a | |
| YFV VACCINE RECORD | 2001 | NV | NV | NV | NV | NV | NV | NV | NV | NV | NV | NV | NV | |
|
| ||||||||||||||
| Admission day | DPS | 6 | 13 | 4 | 1 | 5 | 3 | 5 | 11 | 2 | 3 | 3 | 3 | 2 |
| Death day | 9 | 25 | * | 6 | 9 | 7 | * | 41 | 8 | 4 | 9 | 6 | 7 | |
| Admission day | Fever | P | P | P | P | P | P | P | P | P | P | P | P | P |
| Death day | A | A | * | 0 | P | A | * | n/a | A | A | A | A | A | |
| Admission day | Headache | P | P | A | P | P | A | P | P | P | P | A | P | P |
| Death day | 0 | 0 | * | A | A | A | * | n/a | A | A | A | A | A | |
| Admission day | Confusion | P | P | A | 0 | P | A | A | P | A | P | P | A | A |
| Death day | 0 | P | * | A | A | A | * | n/a | P | A | A | P | A | |
| Admission day | Seizure | P | A | A | 0 | 0 | A | A | A | A | P | P | A | A |
| Death day | A | A | * | 0 | 0 | A | * | n/a | A | A | A | P | P | |
| Admission day | Other neurological disorder | coma | A | A | A | A | A | A | A | A | A | A | A | A |
| Death day | coma | coma | * | coma | coma | A | * | n/a | A | coma | A | A | A | |
| Admission day | Jaundice | P | P | P | P | P | P | P | P | A | P | P | P | P |
| Death day | P | P | * | A | P | A | * | n/a | P | A | P | A | A | |
| Admission day | Platelets | 34,000 | 87,000 | 86,000 | 55,000 | 162,000 | 62,000 | 55,000 | 61,000 | 96,000 | 10,200 | 40,000 | 46,000 | 81,000 |
| Death day | (150,000 – 400,000 mm3) | 75,000 | 67,000 | * | 59,000 | 89,000 | 57,000 | * | 67,000 | 109,000 | 67,000 | 47,000 | 70,000 | 57,000 |
| Admission day | Neutrophils | 7,458 | 7,544 | 4,536 | 1,200 | 13,600 | 4,712 | 3,016 | 1,872 | 1,098 | 3,844 | 3,936 | 5,472 | n/a |
| Death day | (2,000 – 8,250 mm3) | n/a | n/a | * | n/a | n/a | n/a | * | n/a | n/a | n/a | n/a | n/a | n/a |
| Admission day | Creatinine | 7.2 | 1 | 4.7 | 1 | 8.1 | 4.4 | 5.2 | 1.9 | 1.4 | 1.3 | 0.6 | 5.7 | 1.7 |
| Death day | (0.7 – 1.30 mg/dL) | 6.8 | 5.5 | * | 5.6 | 5.6 | 6.1 | * | 4.9 | 5.6 | 5.9 | 4.4 | 4.7 | 4.6 |
| Admission day | Albumin | 2.7 | 1.9 | n/a | 2.9 | 3 | 2.5 | 2.6 | 2.5 | 3.6 | 2.8 | 3.3 | 2.1 | 3.2 |
| Death day | (3.4 – 4.5 g/dL) | 2.2 | 2.4 | * | 2.8 | n/a | 2.5 | * | 2.4 | 2.4 | 3.2 | 2.1 | 3.4 | |
| Admission day | AST | 14,060 | 231 | 410 | 7,491 | 17,000 | 6,674 | 8,369 | 7,630 | 4 | 5,475 | 7,679 | 19,000 | 13,437 |
| Death day | (10 – 40 U/L) | 4,019 | 574 | * | 14,928 | 4,943 | 4,807 | * | 120 | 7,269 | 15,098 | 5,141 | 4,728 | 9,228 |
| Admission day | ALT | 5,681 | 668 | 3,800 | 5,029 | 13,544 | 4,417 | 4,000 | 2,390 | 4,227 | 176 | 5,059 | 4,708 | 6,178 |
| Death day | (10 – 40 U/L) | 1,896 | 171 | * | 5,790 | 2,735 | 2,376 | * | 52 | 131 | 2,049 | 3,705 | 878 | 2,324 |
| Admission day | TBil | 7.2 | 21.7 | 5 | 2.9 | 4.9 | 13.6 | 6.8 | 9.9 | 1.7 | 5.6 | 4.8 | 6.3 | 2.8 |
| Death day | (0.3 – 1.0 mg/dL) | 7.4 | n/a | * | 13.3 | 6.9 | 18.1 | * | 29.4 | 14.5 | 5.6 | 16.7 | 4.7 | 10.1 |
| Admission day | Dbil | 6.7 | 19.7 | 2.2 | 2.2 | 3.2 | 13 | 6.5 | 8.6 | 1.3 | 5.6 | 3.7 | 5.9 | 2.3 |
| Death day | (0.1 – 0.3 mg/dL) | 6.4 | 29.9 | * | 12 | 3.1 | 17.4 | * | 26 | 13.9 | 3.8 | 14.2 | 4.3 | 8.6 |
| Admission day | GGT | 210 | 172 | n/a | 151 | n/a | 422 | 165 | 397 | 82 | 169 | 661 | 189 | n/a |
| Death day | (9 – 50 U/L) | 156 | 126 | n/a | 194 | 164 | 346 | * | 108 | 131 | 96 | 188 | 116 | 186 |
| Admission day | Aphos | 158 | 109 | n/a | 120 | 234 | 215 | 77 | 187 | 84 | n/a | 68 | 109 | n/a |
| Death day | (30 – 120 U/L) | 254 | 199 | n/a | 394 | 982 | 206 | * | 224 | 121 | 147 | 98 | 104 | 212 |
| Admission day | INR | 3.99 | 1.78 | 4.82 | 2.39 | 9.27 | 1.47 | 1.99 | 2.01 | 1.82 | 6 | 1.57 | 1.89 | 1.31 |
| Death day | 2.86 | 1.69 | * | 4.61 | > 5.00 | 1.15 | * | 1.17 | n/a | 3.4 | 2.95 | 1.97 | 1.58 | |
*
data from admission and death day are the same. P 1 – P 13, patient 1 to 13 DPS, days post symptom onset; NR, non-reactive; n/a, not available; NV, non-vaccinated; P, presence; A, absence; AST, aspartate aminotransferase; ALT, alanine aminotransferase; Tbil, Total bilirubin; Dbil, Direct bilirubin; GGT, gamma-glutamyl transferase; APhos, alkaline phosphatase; INR, international normalized ratio. Laboratory test reference ranges followed ABIM (26).