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The “vicious vortex” in bronchiectasis, the key role of neutrophilic inflammation and the expected effects of inhibiting cathepsin C during myelopoiesis. A1AT: α-1 antitrypsin; CatC: cathepsin C; CatG: cathepsin G; ECM: extracellular matrix; IL-1β: interleukin-1β; IL-8: interleukin-8; MMP: matrix metallopeptidase; NE: neutrophil elastase; NSP: neutrophil-derived serine protease; PR3: proteinase 3; SLPI: secretory leukocyte peptidase inhibitor; TNF-α: tumour necrosis factor-α.
