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. 2023 Jul 5;17(7):e0011089. doi: 10.1371/journal.pntd.0011089

Fig 2. Higher CAA concentration pre-vaccination is associated with a reduction in Hepatitis B vaccine titers.

Fig 2

(A) Density of Schistosome-specific antigen values (CAA [pg/ml]) analyzed in serum samples from participants pre-vaccination (D0). A binomial distribution was fitted to the CAA values and a maximum-likelihood was used to identify the optimum cutoff separating the two modes of the CAA values. Two groups of participants were then identified based on CAA values [low CAA (<36pg/mL CAA), n = 41; high CAA (≥36pg/mL CAA), n = 33]. Male (blue line), n = 53; Female (red line), n = 21 (B) Hepatitis B (HepB) titers (log pg/mL) determined by commercial immunoassays for individuals at M7 post-vaccination plotted to compare low and high CAA. Participants were further defined based on CAA concentration values using methodology from the CAA assay that allowed detection of samples as low as 3pg/mL [non-infected [no] (<3pg/mL CAA), low CAA [low] (3–100 pg/mL CAA), and high CAA [high] (>100pg/mL CAA)]. HepB titers for individuals at (C) Month 7 post-vaccination [non-infected n = 16, low CAA, n = 26 and high CAA, n = 22] and (D) Month 12 post-vaccination [non-infected, n = 14, low CAA, n = 23, high CAA, n = 19] plotted to compare CAA. Boxplots show median values (horizontal line), interquartile range (box) and 95% confidence interval (whiskers).