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. 2023 Jul 5;17(7):e0011089. doi: 10.1371/journal.pntd.0011089

Fig 6. Monocyte function is important in and significantly correlate with Hepatitis B vaccine responses.

Fig 6

Antibody-dependent cellular phagocytosis (ADCP) assays conducted with serum [pre-vaccination- non-infected, n = 14, low CAA, n = 20, high CAA, n = 18] and cells from the monocyte cell line THP-1. Scatter plots show HBsAg-specific ADCP associations with (A) Hepatitis B titers at M12, and with (B) HBsAg-specific IgG1, and (C) HbsAg-specific antibody binding to FcγR3A (CD16) expression determined by antibody subclass and Fc receptor binding assays. Spearman correlation and t-test were used to evaluate for the significance of the correlation. coef (regression coefficient). t (t-statistic). P ≤ 0.05 was considered significant. (Shape: triangle-Male, circle-Female; color: grey- non-infected, black- low CAA, blue- high CAA).