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. 2023 Jul 5;17(7):e0011089. doi: 10.1371/journal.pntd.0011089

Fig 7. Lower levels of cytokines/chemokines important in innate immune cell function in S. mansoni-infected individuals pre-vaccination and day 12 post-vaccination.

Fig 7

(A) CXCL10 levels pre-vaccination (D0) [non-infected, n = 19, low CAA, n = 31, and high CAA, n = 25], and (B) IL-1β, and (C) CCL26levels at D12 post vaccination [non-infected, n = 15, low CAA, n = 26, high CAA, n = 23] in the culture supernatant of PBMCs stimulated for 18 hours with CLO97 (TLR7/8 agonist) or untreated (UNT). Data shown as ± SEM. * P ≤ 0.05 Wilcoxon matched-pairs signed rank test performed on UNT vs. CLO97 or each non-infected, or low CAA, or high CAA, and within the CLO97-treated group a Wilcoxon rank-sum test on non-infected vs. low CAA, or non-infected vs. high CAA, or low CAA vs. high CAA. Non-infected- light grey, low CAA—blue, and high CAA—dark grey.