Table 3. Two-way mixed model ANOVA post hoc multiple comparison of participants’ physical function and quality of life scores.

Variable	Time frame	OKCE (n=20) Mean±SD	CKCE (n=20) Mean±SD	Control (n=20) Mean±SD	Time		Group × time
					F	p-value	F	p-value
WOMAC Pain	Baseline	9.70±4.15	8.90±4.27	10.15±3.66	27.984	<0.001*	10.519	<0.001*#
	6th week	6.65±3.66	5.80±5.27	10.80±4.26
	12th week	6.65±4.35	6.00±5.43	10.30±4.49
WOMAC Stiffness	Baseline	3.95±1.35	4.15±1.08	3.90±1.11	51.510	<0.001*	12.275	<0.001*#
	6th week	2.30±1.08	2.50±1.31	3.85±1.42
	12th week	2.35±1.38	2.55±1.27	3.90±1.88
WOMAC Physical function	Baseline	33.20±9.32	33.55±10.31	32.90±8.76	115.030	<0.001*	24.471	<0.001*
	6th week	23.65±9.61	24.05±9.94	32.60±8.42
	12th week	23.00±9.59	24.15±10.58	32.65±8.59
SF-36 Physical Functioning	Baseline	44.00±4.75	44.30±4.56	45.25±5.25	13.639	<0.001*	5.377	<0.001*#
	6th week	52.75±11.41	54.80±12.57	44.50±9.58
	12th week	52.00±14.81	55.05±15.71	43.25±11.72
SF-36 Role Limitations (Physical)	Baseline	11.50±11.36	16.00±11.42	13.00±9.23	56.00	<0.001*	114.00	<0.033*#
	6th week	26.00±9.94	22.50±11.18	14.00±10.46
	12th week	28.00±10.05	24.00±12.73	13.50±12.25
SF-36 Pain	Baseline	30.75±16.74	30.25±13.76	31.12±17.61	14.057	<0.001*	4.313	<0.003*#
	6th week	49.50±25.75	49.00±19.62	30.05±20.04
	12th week	48.25±23.84	49.62±27.91	29.25±21.38
SF-36 General Health Perception	Baseline	53.50±22.48	51.75±22.95	51.75±19.68	54.891	<0.001*	14.932	<0.001*
	6th week	71.25±20.25	69.25±21.23	51.00±20.65
	12th week	70.75±20.14	68.75±22.64	51.00±22.10
SF-36 Mental Health	Baseline	56.40±13.35	58.80±13.11	59.00±15.94	10.211	<0.001*	3.310	<0.001*#
	6th week	73.20±9.97	69.40±9.20	59.20±6.43
	12th week	68.80±11.50	62.20±14.76	58.80±7.00

*Significant difference; CG: control group; ^#significant difference with the control group.