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. 2023 Jun 15;30(7):958–969. doi: 10.1038/s41594-023-01014-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Alignment generated from the structural superposition of SNX1^BAR and SNX5^BAR central regions. Alignments also include per-residue energetic contribution in theoretical SNX1 and SNX5 homodimers generated by homology modeling using our SNX1^BAR-SNX5^BAR crystal structure as template. Energetic values in each row correspond to the molecule highlighted in bold within the respective complex. Red boxes mark residues that were mutated to interfere with dimerization. Red boxes with an asterisk indicate residues that were mutated to promote SNX5 dimerization.