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. 2023 Jun 15;30(7):958–969. doi: 10.1038/s41594-023-01014-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, 3D reconstruction of the ESCPE-1 coat. The SNX1–SNX5 atomic model has been fitted and symmetrized according to the arrangement calculated from the three-start helix parameters. Amphipathic helices responsible for the lateral expansion of lipids are in red. b, Model for the endosomal sorting of ESCPE-1 cargos. The presence of cargo promotes SNX1–SNX5 recruitment and the shaping of a tubular carrier in conjunction with pushing forces produced by actin polymerization and pulling forces produced by molecular motors.