Table 1.
Pharmacokinetic parameters of minzasolmin in C57/Bl6 mice following single dose intraperitoneal administration of 1 or 5 mg/kg.
| PLASMA | |||||
| Dose (mg/kg/day) | T max (h) | C max (ng/mL) | AUC last (h*ng/mL) | AUC inf (h*ng/mL) | Half-life (h) |
| 1 | 0.5 | 332 ± 18 | 307 ± 13 | 308 | 0.69 |
| 5 | 0.25 | 1317 ± 124 | 1635 ± 86 | 1648 | 0.83 |
| BRAIN | |||||
| Dose (mg/kg/day) | T max (h) | C max (ng/mL) | AUC last (h*ng/g) | AUC inf (h*ng/g) | Half-life (h) |
| 1 | 0.5 | 76.0 ± 4.0 | 93.9 ± 4.2 | 99.0 | 0.56 |
| 5 | 0.5 | 292 ± 30 | 394 ± 21 | 422 | 0.60 |
Data presented as the group mean ± SEM; 5 sampling timepoints × 3 mice/timepoint.
AUCinf (Area under the curve from time 0 extrapolated to infinity (inf)) was used to calculate brain to plasma ratios. The density of brain homogenate was considered as 1 which is equivalent to plasma density.