Table 2.

Attributes of node types and their sources.

Entity type	Property	Source	Description	Entities with property
Birth defect	MedDRA code		MedDRA ontology identifier	32
Drug	Placenta crossing likelihood score	Drugshot	Cosine similarity score to L1000 gene expression signatures for drugs known to cross the placental barrier	4523
	Placenta crossing likelihood rank	Drugshot	Rank (1=most similar) of cosine similarity score to L1000 gene expression signatures for drugs known to cross the placental barrier	4523
	SMILES	PubChem	SMILES structure	4084
Gene	pLI	Exome Aggregation Consortium (ExAC)	Probability of loss-of-function intolerance	9466
	pHI	Collins et al.62	Haploinsufficiency score	9466
	pTS	Collins et al.62	Triplosensitivity score	9466
	Residual Variant Intolerance Score	NHLBI Exome Sequencing Project	Ratio of functional mutations to total variant sites	9466
	Residual Variant Intolerance Score Percentile	NHLBI Exome Sequencing Project	Percentile of RVIS across all scored genes	9466

The ReproTox-KG is made of entities (nodes) representing birth defects, genes, and drugs that are decorated with attributes and properties associated with them, for example, common identifiers. The table lists the properties and their sources for each entity type, namely, birth defects, genes, and drugs represented in the ReproTox-KG.