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. 2023 Jul 17;9:252. doi: 10.1038/s41420-023-01538-3

Fig. 7. Administration of MMS350 reduce numbers of lung senescent cells and profibrotic gene product levels in thoracic-irradiated mice.

Fig. 7

A Expression of luciferase gene in control (No IR), irradiated (IR), IR + MMS350, and IR + TL02-59 in thoracic-irradiated p16-LUC+ mice at day 120. B Expression of TGF-β, Collagen 1a1, and Collagen 3 in non-irradiated control (C57BL/6), thoracic-irradiated (IR, 18 Gy), (3) IR + Fgr inhibitor TL02-59 (10 mg/kg at day 30 after IR, 3 days a week for 4 weeks), (4) IR + MMS350 (100ug/ml in drinking water) and (5) IR + TL02-59 + MMS350 treated mice as measured by qPCR. p values were obtained by one-way ANOVA. (n = 4–5).