Fig. 8. Senescent cell numbers and Fgr-positive cells are increased in IPF and RIPF patient lung histopathologic sections.

A Surgically resected human lungs and age-matched control lungs were stained for Fgr and p16. Third panel shows merged images of Fgr and p16 with blue nuclear stain DAPI (×20). Far right column shows enlarged areas (boxes). Images are representative of samples from three patients in each lung pathology. P16 and Fgr-positive cells were quantified from both IPF and RIPF sections. B Human RIPF sections were stained with Fgr and co-stained with F4/80 for monocytes, macrophages, and dendritic cells. C Human RIPF sections were stained with Fgr and co-stained with CD11b for inflammatory alveolar macrophages. Quantification of Fgr and p16-positive cells are shown on the right. (n = 3, p values were calculated by ANOVA Turkey’s multiple comparison test).