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. 2023 Jul 17;14(7):445. doi: 10.1038/s41419-023-05944-4

Fig. 6. BCKDK promotes BRCA metastasis in vivo.

Fig. 6

A Luciferase-labeled MDA-MB-231 (MDA-MB-231-Luciferase) cells were injected into 10 female nude mice via tail vein injection. Lung metastasis was monitored by bioluminescence using an in vivo imaging system in the left panel. Number of metastatic nodules in the lung. Error bars represent the mean ± SD. (*means P < 0. 001). B H&E staining of lungs from the indicated groups upon harvest (day 21). Scale bars, 100 µm. C, D The expression of p-FAK and p-ERK1/2 in nude mice lung tissue was detected by immunohistochemistry. Scale bars, 100 µm. E The schematic diagram of the role of BCKDK/talin1 signaling axis in affecting the adhesion mechanism of breast cancer cells.