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. 2023 Jul 17;14(7):439. doi: 10.1038/s41419-023-05966-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Relative growth curves of 143B and SJSA1 cells stably transduced with nontargeting scrambled control shRNA (shCont) or two MLX shRNAs (shMLX#1 and shMLX#2). Data are represented as mean ± SD, n = 3. Unpaired one-way ANOVA test followed by Dunnett’s test was used. B Invasion assay conducted in shMLX versus shCont in 143B (upper panel) and SJSA1 (lower panel). Data are represented as mean ± SD, n = 3. Unpaired t-test was used. C Sphere formation assay in 143B (upper panel) and SJSA1 cells (lower panel). Data are represented as mean ± SD, n = 3. Unpaired t-test was used. D Representative images of tumor growth in 143B-derived orthotopic model (n = 5 per group). Unpaired t-test was used. E The representative images of metastasis in 143B-derived orthotopic model (n = 5 per group). Unpaired t-test was used. F Representative images of H&E, Ki-67 and MLX staining of 143B-shCont and 143B-shMLX tumors and the respective analyses (scale bar = 50 μm). Data are represented as mean ± SD, n = 3. Unpaired t-test was used. ***: P ≤ 0.001, **: P ≤ 0.01, *: P ≤ 0.05, n.s.: not significant.