Table 2.
The characteristics of MEX3 family in COSMIC
| Chromosomal location | The distribution of mutations across the primary tissue types | Drug resistance | |||
|---|---|---|---|---|---|
| Point mutations | Copy number variation | Gene expression | |||
| MEX3A | 1q22 | Endometrium (3.09%) | Biliary tract (8.33%) |
Adrenal gland (30.38%) |
None |
| MEX3B | 15q25.2 | Large intestine (4.08%) | Skin (1.02%) |
Urinary tract (9.06%) |
|
| MEX3C | 18q21.1 | Central nervous system (6.72%) |
Stomach (3.39%) |
None | |
| MEX3D | 19p13.3 | Cervix (2.45%) | Ovary (1.32%) |
Adrenal gland (Over-expressed 49.37%; Under-expressed 37.97) |
|
MEX3 muscle excess 3