FIGURE 5.

Elevated plus maze assessment of anxiety‐like behavior in TgF344‐AD rats. (a) Time spent in the open arms of the elevated plus maze for male and female 9‐month‐old and 12‐month‐old rats. (b) Number of entries into the open arms of the elevated plus maze for male and female 9‐month‐old and 12‐month‐old rats. (c) Representative traces of rat paths during the elevated plus maze. Vertical arms are the “open” arms; horizontal arms are the “closed” arms. Data presented as mean ± SEM with points representing individual rats. Statistical analysis was performed by two‐way ANOVA at each age. Post‐hoc analysis was carried out by pairwise comparisons with Benjamini and Hochberg correction applied. N = 7–8 per group.