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. 2023 Jul 4;15:1155630. doi: 10.3389/fnagi.2023.1155630

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Copyright © 2023 Ephrame, Cork, Marshall, Johnston, Shawa, Alghusen, Qiang, Denson, Carman, Fedosyuk, Swerdlow and Slawson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Western blot analysis of total brain lysate of 5XFAD mice subjected to intra-peritoneal TMG injection for 1 month. The blots were probed for panel (A) O-GlcNAc, OGA, OGT, α-Tubulin (B) p-ERK 1/2, Total ERK 1, and APP (D) p-MEK 1/2, MEK 1/2, Dusp4 and α-Tubulin. Densitometry plot of panel (C) ERK 1/2 phosphorylation normalized to total ERK 1 (E) MEK 1/2 phosphorylation normalized to total MEK 1/2 and (F) DUSP4 normalized to α-tubulin in 5XFAD mice brains. The dots represent the number of mice (n = 6 for control and n = 7 for TMG injected mice). Statistical significance was measured using un-paired-t-test analysis and p-value is indicated on the plots. *Indicates p-values that are significant (p < 0.05).