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C57BL/6 males showed less anxiety-like behavior than females. (A) The total travel distance of male and female mice in the open-field test. (B) The time of male and female mice in the center area of the open-field test. (C) The number of male and female mice entered the center area of the open-field test. (D) The distance of male and female mice in the center area of the open-field test. Welch’s t-test, Mean ± S.E.M. (n = 10 for each group).
