Table 2.
Univariate and Multivariate Cox Proportional Hazard Models for Recurrence of HCC
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | |
| Patient characteristics and profiles | ||||
| Age > 75 years | 1.47 (0.52-4.16) | 0.474 | ||
| Men | 1.35 (0.65-2.80) | 0.425 | ||
| BMI > 25 kg/m2 | 0.68 (0.36-1.29) | 0.234 | ||
| Diabetes mellitus | 0.46 (0.20-1.05) | 0.065 | ||
| Albumin < 3.5 g/dL | 1.63 (0.76-3.47) | 0.207 | ||
| Total bilirubin > 1.0 mg/dL | 1.63 (0.84-3.17) | 0.149 | ||
| AST > 35 U/L | 1.03 (0.50-2.14) | 0.935 | ||
| ALT > 40 U/L | 1.30 (0.69-2.46) | 0.42 | ||
| PT | 1.09 (0.86-1.39) | 0.473 | ||
| AFP | 1.0 (0.99-1.00) | 0.408 | ||
| Child-Pugh score | 1.75 (1.10-2.77) | 0.018 | 2.04 (1.23-3.36) | 0.005 |
| Disease parameters (before treatment) | ||||
| Tumor size > 30 mm | 1.30 (0.54-3.15) | 0.558 | ||
| Tumor number | 2.52 (1.14-5.55) | 0.022 | 2.68 (1.20-5.99) | 0.017 |
| BCLC stage A | 1.17 (0.60-2.28) | 0.639 | ||
| Sarcopenia parameter | ||||
| Sarcopenia | 1.68 (0.85-3.32) | 0.137 | 2.06 (0.99-4.27) | 0.052 |
AFP, α-fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BCLC, the Barcelona Clinic Liver Cancer; BMI, body mass index (kg/m2); PT, prothrombin time (second)