Table 3.
The Detected MutationsTypes and Frequency in T-ALL Patients
| Types of mutations | Mutation: nucleotide | Mutation: amino acid |
|---|---|---|
| No. of mutated samples (19/25) | ||
| Point mutation (19/25 )(1 active and 18 silent) | ||
| Exon 18: 1 Samples(active) | c.1866G>C | p.V596L |
| Exon 20: 18 Samples (silent) | c.2219C>T | p.A713A |
| Deletion mutation in Exon 18 ( 4 Samples) | c.1872delA | Frame shift mutation with unknown protein. |
Among the detected mutations 2 novel ones were detected in exon 18, all of them were active, one was point mutation (c.1866G>C), and one was frame-shift mutation (c.1872delA) was detected in 4 samples.