Table 4.
miRNAs encapsulated in VSMC-EVs regulate in the process of VC.
| miRNA | EVs origin | Stimulation | Expression | Function | References |
|---|---|---|---|---|---|
| miR-92b-3p | Rat VSMC | Curcumin | Up | Inhibited VC | (163) |
| miR-204-5p | Calcifying HVSMC | Melatonin | Up | Inhibited VC | (165) |
| miR-211-3p | Calcifying HVSMC | Melatonin | Up | Inhibited VC | (165) |
| miR-19b-3p | MOVAS-1 | β-GP and pyruvic acid | Up | Further researched required | (174) |
| miR-19b-3p | Descending thoracic aorta | Cystic kidney disease | Up | Further researched required | (175) |
| miR-92b-5p | MOVAS-1 | β-GP and pyruvic acid | Up | Further researched required | (174) |
| miR-92b-5p | Descending thoracic aorta | Cystic kidney disease | Up | Further researched required | (175) |
| miR-24-3p | Descending thoracic aorta | Cystic kidney disease | Down | Further researched required | (175) |
EVs, extracellular vesicles; VSMC, vascular smooth muscle cell; HVSMC, human vascular smooth muscle cell; VC, vascular calcification; β-GP, β-glycerophosphate.