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. 2023 Jul 4;13:1189350. doi: 10.3389/fonc.2023.1189350

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Copyright © 2023 Lai, Ahmed, Hwang, Bahar, Pham, Yang, Kim, Maulidi, Lee, Kim, Kim and Kim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of RKIP in response to modulation of its upstream regulators in MCF-7 and MDA-MB-231 cells. (A) Relative RKIP expression and (B) RKIP protein level in response to SNAI1 knockdown (KD) or overexpression (OE) and compared to the wild-type (WT) MCF-7 (upper panel) and MDA-MB-231 (lower panel) cells. (C) Relative RKIP expression and (D) RKIP protein level in response to NME1 knockdown (KD) or overexpression (OE) and compared to the wild-type (WT) MCF-7 (upper panel) and MDA-MB-231 (lower panel) cells. KD #1 and KD #3 are two target-specific shRNA designed to knock down NME1 expression. The relative mRNA expression in RT-qPCR was normalized to GAPDH. Data represent the means ± S.D of six replicates. *< 0.05; ** < 0.01; *** < 0.005 p-values, ns, non-significant.