TABLE 1.
General information of the included studies.
| Article | Species | Specimen | AIS | Control | Tech | DE circRNA | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Age | Sex (M) | N | Age | Sex (M) | Up | Down | ||||
| XP Peng (2019) 15 | Human | PBMCs | 160 | 62.5 ± 12.9 | 109 | 160 | 60.6 ± 10.7 | 114 | qRT‐PCR | 1 | / |
| XQ Zhu (2019) 32 | Human | PBMCs | 170 | 64.9 ± 12.5 | 124 | 170 | 63.9 ± 10.5 | 131 | qRT‐PCR | / | 1 |
| Y Chen (2020) 34 | Human | Serum | 80 | 57.0 ± 21.1 | 53 | 30 | 56.0 ± 20.9 | 20 | Microarray | 4 | 4 |
| qRT‐PCR | 1 | / | |||||||||
| ZF Dong (2020) 35 | Human | PBMCs | 5 | 47–69 | 4 | 5 | 45–62 | 3 | Sequencing | 373 | 148 |
| qRT‐PCR | 4 | 4 | |||||||||
| SH Li (2020) 36 | Human | Whole blood | 3 | NA | NA | 3 | NA | NA | Sequencing | 659 | 1611 |
| 32 | NA | NA | 32 | NA | NA | qRT‐PCR | 1 | 2 | |||
| Y Zhao (2020) 37 | Human | Serum | 90 | NA | NA | 75 | NA | NA | qRT‐PCR | / | 1 |
| L Zuo (2020) 19 | Human | Whole blood | 3 | 63.0 ± 1.5 | 1 | 3 | 59.3 ± 2.6 | 1 | Microarray | 10 | 68 |
| 36 | 66.3 ± 13.3 | 17 | 36 | 66.4 ± 13.2 | 17 | qRT‐PCR | 3 | / | |||
| 200 | 61–82 | NA | 100 | 59–71 | NA | qRT‐PCR | 3 | / | |||
| SN Li (2021) 38 | Human | PBMCs | 5 | 60.33 ± 9.53 | 3 | 4 | 58.55 ± 8.55 | 2 | Sequencing | 182 | 176 |
| 30 | 62.16 ± 8.95 | 16 | 30 | 61.25 ± 9.07 | 15 | qRT‐PCR | 3 | 3 | |||
| 168 | 62.53 ± 8.70 | 87 | 118 | 61.84 ± 8.93 | 65 | qRT‐PCR | 1 | / | |||
| Q Xiao (2021) 33 | Human | Plasma (exosomes) | 5 | NA | NA | 5 | NA | NA | Sequencing | 9 | 16 |
| 32 | NA | NA | 32 | NA | NA | qRT‐PCR | / | 5 | |||
| L Yang (2020) 20 | Human | Plasma | 3 | NA | NA | 3 | NA | NA | Microarray | 4 | 16 |
| 12 | NA | NA | 12 | NA | NA | qRT‐PCR | 5 | 4 | |||
| 145 | 60–75 | 80 | 145 | 61–82 | 84 | qRT‐PCR | / | 1 | |||
| C57BL/6J mice | Plasma | 6 | 8–10 w | All | 6 | 8–10 w | All | qRT‐PCR | / | 1 | |
| Y Bai (2018) 39 | Human | Plasma | 26 | 65.4 ± 2.03 | 13 | 26 | 66.9 ± 2.30 | 13 | qRT‐PCR | / | 1 |
| C57BL/6J mice | Ipsilateral hemisphere | NA | 8–10 w | All | NA | 8–10 w | All | qRT‐PCR | / | 1 | |
| B Han (2018) 14 | Human | Plasma | 37 | 68.50 ± 1.36 | 18 | 34 | 70.19 ± 1.42 | 19 | qRT‐PCR | 1 | / |
| C57BL/6J mice | Ischemic cortex | 3 | 6–8 w | All | 3 | 6–8 w | All | qRT‐PCR | 1 | / | |
| FF Wu (2019) 21 | Human | Plasma | 71 | 68.56 ± 1.07 | 59 | 71 | 67.86 ± 1.30 | 59 | qRT‐PCR | 1 | / |
| C57BL/6J mice | Plasma & ischemic cortex | 13&8 | 8–10 w | All | 13&8 | 8–10 w | All | qRT‐PCR | 1 | / | |
| D Lu (2020) 40 | Human | Whole blood | 8 | 55.4 ± 12.3 | 7 | 8 | 54.11 ± 10.1 | 7 | qRT‐PCR | / | 2 |
| Balb/c mice | Whole blood | 3 | 10–12 w | All | 3 | 10–12 w | All | Microarray | Totally 198 | ||
| Blood & ischemic brain | 3 | 10–12 w | All | 3 | 10–12 w | All | qRT‐PCR | 3 | 2 | ||
| SL Mehta (2017) 41 | C57BL/6 mice | Ischemic penumbral cortex | 3 | 12 w | All | 3 | 12 w | All | Microarray | 8 | 8 |
| qRT‐PCR | 3 | 3 | |||||||||
| XL Yang (2018) 42 | C57BL/6 mice | Brain cortical tissues | 10 | 8–10 w | All | 10 | 8–10 w | All | qRT‐PCR | 1 | / |
| WH Chen (2020) 27 | C57BL/6 mice | Brain tissues | 6 | 6–8 w | All | 6 | 6–8 w | All | qRT‐PCR | / | 1 |
| CG Tang (2020) 43 | C57BL/6 mice | Hippocampus | NA | 6–8 w | All | NA | 6–8 w | All | qRT‐PCR | 1 | / |
| LQ Wu (2020) 44 | C57BL/6 mice | Brain tissues | 5 | 8–10 w | All | 5 | 8–10 w | All | qRT‐PCR | / | 1 |
| ZH Zhang (2020) 45 | Sprague Dawley rats | Neocortex of left frontal pole | 4 | NA | All | 4 | NA | All | Sequencing | 16 | 28 |
| qRT‐PCR | 3 | 5 | |||||||||
| QD Dai (2021) 13 | C57BL/6 mice | Brain tissues & serum | 3 | 2 m | All | 3 | 2 m | All | qRT‐PCR | 1 | / |
| B Yang (2021) 46 | C57BL/6 mice | Brain tissues | 5 | 6 w | All | 5 | 6 w | All | qRT‐PCR | 1 | / |
| ZD Zhang (2021) 47 | Vital River Lab mice | Brain tissues | NA | 10 w | All | NA | 10 w | All | qRT‐PCR | 1 | / |