Table 1.

Effects of genetically predicted total bilirubin on cholelithiasis and cholelithiasis on total bilirubin in the MR analysis.

Exposure	Outcome	No. of SNP	Method	β (95% CI)	p-val	Egger_intercept	P-Egger_intercept
Total bilirubin	Cholelithiasis	116	Random-effect IVW	0.10 (0.07 to 0.14)	<0.001	−0.0031	0.098
			Weighted median	0.12 (0.08 to 0.15)	<0.001
			MR-Egger	0.11 (0.08 to 0.15)	<0.001
			Weighted mode	0.11 (0.08 to 0.15)	<0.001
Cholelithiasis	Total bilirubin	7	Random-effect IVW	0.12 (0.09 to 0.15)	<0.001	−0.0007	0.852
			Weighted median	0.10 (0.06 to 0.13)	<0.001
			MR-Egger	0.12 (0.07 to 0.18)	0.007
			Weighted mode	0.09 (0.03 to 0.14)	0.019