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. 2023 Jul 4;14:1211332. doi: 10.3389/fphar.2023.1211332

TABLE 1.

Potential drug-hub gene interaction predicted by DGIdb database.

Gene Potential drug Interaction score Drug class Drug indication
IL1R2 ANAKINRA 7.73 IL1R antagonist Rheumatoid arthritis
FOS BACLOFEN 1.24 Muscle relaxant Multiple sclerosis
MMP9 ANDECALIXIMAB 10.30 MMP9 antibody Gastric cancer
DUSP1 ALBUTEROL 6.87 β2 adrenergic agonist Acute asthma
CLEC4D N/A N/A N/A N/A

Abbreviations: DGIdb, drug-gene interaction database; IL1R, interleukin-1, receptor; CGRP, calcitonin gene-related peptide; FOS, Fos proto-oncogene; MMP9, matrix metallopeptidase 9; DUSP1, dual specificity phosphatase 1; CLEC4D, C-type lectin domain family 4 member D.