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. 2023 Jul 4;14:1176292. doi: 10.3389/fgene.2023.1176292

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Copyright © 2023 Lin, Wang, Liu, Zhao and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ASRS reflects immunotherapy response. The low ASRS is associated with a better response to immunotherapies in an anti-PD-L/PD-L1 cohort (Kim cohort 2019, (A), an anti-PD-L1 cohort (IMvigor210 cohort 2018, (B), and two anti-CTLA-4 cohorts (Nathanson cohort 2017, (C); VanAllen cohort 2015, (D).