. 2023 Jun 22;6(7):982–996. doi: 10.1021/acsptsci.3c00085

Table 3. Pharmacokinetic Data of Ruthenium Complexes.

Ru complex	Dose	Cl_tot(mL h^–1)	V_d(L)	T_1/2(h)
In Phase I Clinical Trials(46)
NAMI-A	300 mg m^–2	7.8	7.9	49
KP1019	600 mg	56.4	5.43	68.1

In Swiss CD-1 Mice(39)
RAPTA-C	4 × 100 mg/kg/day	6.5	0.1	10.39
	2 × 200 mg/kg/day	9.2	0.163	12.21
	1 × 200 mg/kg/day	9.0	0.153	11.47