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. 2023 Jul 4;6(7):1052–1074. doi: 10.1021/acsptsci.3c00084

Table 5. Effective Concentrations of MARK4 Inhibitors Causing 50% Loss of Cell Viability (EC50 Values) in HeLa and U87MG Cancer Cell Linesa.

  EC50 (μM)
compound HeLa U87MG MDA-MB-435 U251 HGFs
23a 2.13 ± 0.08 4.13 ± 0.06 1.76 ± 0.06 7.98 ± 0.21 3.55 ± 0.08
23b 2.52 ± 0.07 4.22 ± 0.12 ND ND ND
23c 2.16 ± 0.03 3.51 ± 0.09 ND ND ND
16a >50 >50 >50 >50 >50
16b >50 >50 ND ND ND
16c >50 >50 ND ND ND
a

Results are presented as mean ± SE of three independent experiments. ND = Not determined.