TABLE 1.
Parameter | Estimatea | %RSE |
---|---|---|
Ka (1/h) | 0.46 | 66 |
V/F (ml) | 73.3 | 41 |
CL/F (ml/h) | 28.0 | 18 |
RUV (%CV) | 29 | 29 |
t1/2 (h) | 1.8 |
CL, clearance; %CV: percent coefficient of variation; F, bioavailability; Ka, absorption rate constant; %RSE: percent relative standard error of the parameter estimate; RUV, residual unexplained variability; t1/2, plasma elimination half-life; V, volume of distribution.
aEstimates are for typical rat (250 g).