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. 2023 Aug;386(2):259–265. doi: 10.1124/jpet.122.001377

TABLE 1.

Levetiracetam pharmacokinetic parameter estimates using a first-order, one-compartment PK model

Parameter Estimatea %RSE
Ka (1/h) 0.46 66
V/F (ml) 73.3 41
CL/F (ml/h) 28.0 18
RUV (%CV) 29 29
t1/2 (h) 1.8

CL, clearance; %CV: percent coefficient of variation; F, bioavailability; Ka, absorption rate constant; %RSE: percent relative standard error of the parameter estimate; RUV, residual unexplained variability; t1/2, plasma elimination half-life; V, volume of distribution.

aEstimates are for typical rat (250 g).