. 2023 Aug;104(2):51–61. doi: 10.1124/molpharm.123.000671

TABLE 2.

Fold induction of known NRF2 target gene transcripts in liver of wild-type, Keap1 C151S mutant, and Nrf2-knockout (KO) mice following one or three doses of vehicle or 30 µmol/kg CDDO-Me

		Nqo1		Gstm1		Gpx2		Srnx1		Cbr3
		1 Dose	3 Doses	1 Dose	3 Doses	1 Dose	3 Doses	1 Dose	3 Doses	1 Dose	3 Doses
Wild-type	Vehicle	1 ± 0.48^a	1 ± 0.36	1 ± 0.15	1 ± 0.41	1 ± 0.26	1 ± 0.24	1 ± 0.14	1 ± 0.37	1 ± 0.10	1 ± 0.47
	CDDO-Me	7.93 ± 1.25^b	7.06 ± 1.20^b	3.49 ± 1.23^b	3.25 ± 0.67^b	4.54 ± 0.64^b	13.09 ± 3.71^b	4.59 ± 1.37^b	3.04 ± 0.79^b	43.70 ± 13.72^b	69.50 ± 30.57^b
C151S	Vehicle	0.56 ± 0.05	0.68 ± 0.43	0.42 ± 0.20	1.1 ± 1.10	0.59 ± 0.08	0.99 ± 0.50	0.32 ± 0.08	1.05 ± 0.88	0.53 ± 0.16	1.05 ± 0.99
	CDDO-Me	0.62 ± 0.11	0.55 ± 0.44	0.31 ± 0.11	0.42 ± 0.20	0.60 ± 0.17	0.60 ± 0.22	0.41 ± 0.20	1.14 ± 0.31	0.60 ± 0.10	0.70 ± 0.13
NRF2KO	Vehicle	0.07 ± 0.03	0.11 ± 0.02	0.07 ± 0.02	0.16 ± 0.02	0.46 ± 0.16	0.38 ± 0.09	0.17 ± 0.02	0.31 ± 0.11	0.18 ± 0.04	0.30 ± 0.08
	CDDO-Me	0.14 ± 0.07	0.11 ± 0.04	0.05 ± 0.01	0.11 ± 0.42	0.42 ± 0.04	0.39 ± 0.06	0.37 ± 0.18	0.26 ± 0.09	0.33 ± 0.19	0.52 ± 0.09^b

^aAll values for gene expression levels are shown as mean ± S.D. (N = 3).

^bP < 0.05 using t test. After controlling for 30 multiple comparisons with Bonferroni correction, only Nqo1 (one and three doses) reached statistical significance (P < 0.00167).