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Global regulation of mRNA transcription by the decay machinery. Two models that explain how the Xrn1 nuclease might regulate transcription. Top, Xrn1 is a subunit of a decaysome complex that directly associates with gene promoter sequences and activates both transcription initiation and elongation by RNAPII. Bottom, Xrn1 promotes expression of a global negative repressor of transcription, Nrg1.
