TABLE 4.

Final model of the maximum absolute QTcF^a

Parameter	Value (% RSE)
Typical QTcFmax, θTYP (ms)	380 (0.7)
Effect of taking both clofazimine and moxifloxacin on QTcFmax, θCFZ+MFX (ms)	13.0 (26.9)
Effect of age on QTcFmax, θage (ms/yr)	3.8 (12.8)
Between-subject variability, ηBSV (ms)	18.5 (11.1)
Residual additive error, ε (ms)	14.2 (8.7)

^a

Abbreviations: QTcF, QT interval corrected by Fridericia formula; QTcF_max, maximum absolute QTcF after drug administration. The final model described levofloxacin-based regimens (QTcF_max,LFX) and moxifloxacin- or clofazimine-based regimens (QTcF_max,MFX/CFZ) separately and was a function of age (θ_age) and concomitant drug use:

$${\text{QTcF}}_{\text{max},\text{LFX}}\hspace{0.17em}={\theta }_{\text{TYP}}\hspace{0.17em}+\hspace{0.17em}{\theta }_{\text{age}}\hspace{0.17em}\times \hspace{0.17em}\left(\text{age}\hspace{0.17em}-\hspace{0.17em}2.83\right)\hspace{0.17em}+\hspace{0.17em}{\eta }_{\text{BSV}}\hspace{0.17em}+\text{ε}$$

$${\text{QTcF}}_{\text{max},\text{MFX/CFZ}}\hspace{0.17em}={\theta }_{\text{TYP}}\left(1\hspace{0.17em}+\hspace{0.17em}{\theta }_{\text{CFZ/MFX}}\right)\hspace{0.17em}+\hspace{0.17em}{\theta }_{\text{age}}\hspace{0.17em}\times \hspace{0.17em}\left(\text{age}\hspace{0.17em}-\hspace{0.17em}2.83\right)\hspace{0.17em}+\hspace{0.17em}{\eta }_{\text{BSV}}\hspace{0.17em}+\text{ε}$$