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Combined effect of cefepime dose, dosing interval, and estimated creatinine clearance on both PTA and on the probability of neurotoxicity for an efficacy target of (A) 65% T>MIC and (B) 100% T>2×MIC based on plasma trough cefepime concentrations. The color gradient in the background indicates the estimated risk of neurotoxicity. The black lines represent 90% PTA for assumed MICs ranging from 0.5 to 16 mg/L.
