TABLE 3.
Parameter estimates of cefepime obtained from the final modela
| Parameter | NONMEM |
Bootstrap analysis |
||||
|---|---|---|---|---|---|---|
| Estimate | RSE (%) | Shr (%) | Median | RSE (%) | 95% CI | |
| CLD (L/h) | 2.74 | 13 | 2.71 | 9.26 | 2.29–3.19 | |
| CLND (L/h) | 2.94 | 10 | 2.96 | 12.3 | 2.36–3.78 | |
| V1 (L) | 8.88 | 38 | 9.06 | 17.9 | 5.70–12.2 | |
| Q (L/h) | 27.4 | 54 | 24.7 | 22.4 | 16.8–41.7 | |
| V2 (L) | 18.7 | 22 | 18.0 | 12.4 | 14.2–23.5 | |
| eCLCR effect on CLND | 0.896 | 17 | 0.829 | 13.5 | 0.637–1.04 | |
| IIV CLD (CV %) | 22.7 | 15 | 51 | 20.6 | 37.0 | 12.5–27.9 |
| IIV CLND (CV %) | 31.3 | 20 | 21 | 28.8 | 51.4 | 9.80–40.8 |
| IIV V1 (CV %) | 47.3 | 25 | 14 | 44.2 | 42.3 | 26.7–65.0 |
| IIV V2 (CV %) | 19.3 | 26 | 34 | 19.8 | 51.8 | 5.8–29.7 |
| IOV CLND (CV %) | 22.4 | 23 | 8 | 22.3 | 47.6 | 14.1–35.5 |
| Proportional residual error (SD) | 0.278 | 11 | 0.276 | 14.4 | 0.217–0.324 | |
a
RSE, relative standard error; CI, confidence interval; CLD, elimination clearance in dialysis patients; CLND, elimination in nondialysis patients; V1, central volume of distribution; Q, intercompartmental clearance; V2, peripheral volume of distribution; eCLCR, creatinine clearance estimated by the Cockcroft-Gault equation; IIV, interindividual variability; IOV, interoccasional variability; CV, coefficient of variation; shr, shrinkage; SD, standard deviation.