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Suitable predicted cefepime doses administered q8h with an acceptable risk for neurotoxicity (i.e., 20% or lower, based on average concentration) for selected creatinine clearance valuesa
| CLCR (mL/min) | Dose (mg) required for 90% PTA |
|---|---|
| 30 | 440 |
| 60 | 1,100 |
| 90 | 2,300 |
| 120 | 4,000 |
| 150 | 6,500 |
The MIC target is up to 2 mg/L, and the PK/PD target used is 100% T>2×MIC.
