TABLE 5.
Published cefepime dosing recommendations based on trough concentrations and renal functiona
| eCLCR (mL/min) | Dose regimen | Patient population | Trough concn (mg/L) | Time of infusion | MIC (mg/L) | PKPD target (% T>MIC) | Probability of efficacy and neurotoxicity (%)a | Reference |
|---|---|---|---|---|---|---|---|---|
| 90–130 | 2,000 mg q12h | Hospital-acquired-pneumonia patients | <20 | 4 h | 4 | >50 | NA | 38 |
| 30 | 1,000 mg q12h | ICU patients | ≥20 | 30 min | 8 | 100 | E, 84–92; N, 8–44 | 27 |
| 65 | 1,000 mg q12h | ICU patients | ≥20 | 30 min | 8 | 100 | E, 46–53; N, 1–8 | 27 |
| 120 | 1,000 mg q8h | ICU patients | ≥20 | 30 min | 8 | 100 | E, 40– 44; N, 1–6 | 27 |
a
E, efficacy; N, neurotoxicity; NA, not available.