. Author manuscript; available in PMC: 2023 Jul 18.

Published in final edited form as: J Med Chem. 2020 Apr 15;63(8):4370–4387. doi: 10.1021/acs.jmedchem.0c00371

Table 4.

In vitro experimental Values of T_1/2, intrinsic clearance, and hepatic clearance.

Comp. ID	T_1/2 (min)		CL(int) uL/(min*mg protein)		CL(int,H) mL/(min*kg bodywgt.)
Comp. ID	Mean	SD	Mean	SD	Mean	SD
11	6.13	0.16	113.09	3.02	890.58	23.77
24	2.98	0.17	233.77	13.74	1840.91	108.17
25	3.73	0.03	185.60	1.72	1461.60	13.51
37	6.25	0.16	111.96	2.85	873.80	22.45
40	< 2.00	NA	NA		NA

NA: Not applicable