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. 2023 Jul 18;13(31):21378–21394. doi: 10.1039/d3ra03060a

Effect of temperature on the selectivity of (2S,3R)-10b and (2R,3R)-10b.

Entry Temperature t (h) dr of (2S,3R)-10ba dr of (2R,3R)-10ba
1 r.t. 18 75 : 25 78 : 22
2 −30 °C 18 87 : 13 93 : 7
3 −50 °C 18 94 : 6 100 : 0
a

Ratio was determined by 1H NMR spectral data from crude sample.