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. 2023 Jul 18;13(7):e1331. doi: 10.1002/ctm2.1331

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© 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Correlations between the intratumoural microbiome with clinical characteristics. (A–D) The α‐diversity and β‐diversity of tumour tissues categorised by tumour differentiation and TNM stage. (E) Heatmap indicating the correlations between the differential ASVs of tumour (related to Figure 2E) and clinical indices, including liver function tests, coagulation tests and systemic inflammatory markers derived from routine blood tests. A/G: albumin‐globulin ratio; ALB: albumin; ALP: alkaline phosphatase; ALT: alanine aminotransferase; APTT: activated partial thromboplastin time; AST: aspartate aminotransferase; Dbil: direct bilirubin; FBG: fibrinogen; GGT: gamma‐glutamyl transpeptidase; INR: international normalised ratio; MLR: monocyte‐lymphocyte ratio; NLR: neutrophil‐lymphocyte ratio; PLR: platelet‐lymphocyte ratio; PT: prothrombin time; TBA: total bile acid; Tbil: total bilirubin; TP: total protein; TT: thrombin time; WBC: white blood cell.