TABLE 3.

Estimates of the Mean Increase (Worsening) in ZBPI ADL Individual Component and Total Score for Every Increase of 1 Point in ZBPI Worst Pain Score

	ZBPI ADL component	Estimate	SE	t value	P
ZOE-50/70	General activities	0.57	0.0137	41.13	<0.0001
	Mood	0.51	0.0137	37.22	<0.0001
	Walking ability	0.27	0.0121	22.21	<0.0001
	Normal work	0.47	0.0142	33.04	<0.0001
	Relations with other people	0.33	0.0140	23.88	<0.0001
	Sleep	0.57	0.0147	39.08	<0.0001
	Enjoyment of life	0.49	0.0148	32.84	<0.0001
	ADL Total	0.43	0.0098	44.11	<0.0001
ZOE-HSCT	General activities	0.76	0.0215	35.46	<0.0001
	Mood	0.65	0.0214	30.51	<0.0001
	Walking ability	0.51	0.0225	22.84	<0.0001
	Normal work	0.71	0.0237	29.78	<0.0001
	Relations with other people	0.54	0.0235	22.99	<0.0001
	Sleep	0.68	0.0227	29.93	<0.0001
	Enjoyment of life	0.63	0.0241	26.16	<0.0001
	ADL Total	0.64	0.0168	37.90	<0.0001

ZOE-50/70=Placebo participants from the ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) studies who had an herpes zoster episode.

ZOE-HSCT=Placebo participants from the ZOE-HSCT study (NCT01610414) who had an herpes zoster episode.

The ZBPI Worst Pain score and ADL component and total scores all range from 0 to 10 with a higher score indicating increased pain/negative impact on quality of life.

Estimates, SE, t values, and P-values obtained from the repeated measures, mixed effects model, adjusting for age and sex with random intercept and slope (ie, day of assessment) and ZBPI worst pain score included as a covariate.

ADL indicates activities of daily living; HSCT, hematopoietic stem cell transplantation; ZBPI, Zoster Brief Pain Inventory.