. 2023 Jun 15;9(7):1303–1309. doi: 10.1021/acsinfecdis.3c00031

Table 1. Comparison of the Gene Expression in P. falciparum Induced by DHA, BNTX, or RIMO.

			Fold change^b
Gene name	Gene ID of PF3D7^a	Signal in Pf-cont	Pf-DHA	Pf-BNTX	Pf-RIMO	Type of regulation in Pf-DHA
Glycosylation and glycolysis
(1) ALG14, putative	_0211600	208	0.201	0.686	0.840	DR
(2) GLO1	_1113700	38	0.383	1.839	0.843	DR
(3) tGLO2	_1205700	77	0.204	0.426	1.089	DR
Host invasion
(4) PHISTc	_0801000	210	2.092	0.966	0.330	UR
Lipid
(5) GDPD	_1406300	1651	0.102	0.249	0.439	DR
Microtubule-based process
(6) Alpha tubulin 2	_0422300	152	2.085	1.039	0.289	UR
Mitochondrion
(7) QCR8, putative	_0306000	184	0.122	1.088	0.492	DR
(8) BCKDHA, putative	_1312600	163	2.650	0.740	0.157	UR
Nucleic acid binding and transcription
(9) KH1, putative	_0605100	133	0.458	0.948	2.895	DR
(10) ZFP, putative	_1019300	55	2.181	0.998	0.998	UR
Protein kinase
(11) S/T PK, putative	_1338900	115	0.113	0.866	0.394	DR
Transmembrane transport
(12) MFSP, P115, putative	_1117000	444	0.073	0.330	0.335	DR
(13) MFSP, MFS3, putative	_0919500	55	0.203	0.966	0.621	DR
(14) ZIP1, putative	_0609100	1869	0.269	0.589	1.099	DR
(15) ZIPCO, putative	_1022300	23	0.220	0.348	0.480	DR
(16) CDF, putative	_0715900	765	0.552	0.184	0.254	DR
Other
(17) PfEMP1, pseudogene	_0500200	1105	0.137	1.475	0.316	DR
(18) IMP2, putative	_0730400	123	0.169	0.891	1.093	DR
(19) Conserved Plasmodium membrane protein, UF	_0718700	203	0.184	0.394	1.159	DR
(20) Conserved Plasmodium membrane protein, UF	_1135300	338	0.229	0.610	1.015	DR
(21) Conserved Plasmodium protein, UF	_0628700	619	0.246	0.492	1.271	DR
(22) Plasmodium exported protein, UF, pseudogene	_1478400	2837	0.352	0.732	1.482	DR
(23) Conserved Plasmodium membrane protein, UF	_0924500	1674	0.463	1.784	1.932	DR
(24) Plasmodium exported protein, UF	_1038700	114	5.199	2.094	0.393	UR
(25) DnaJ protein, putative	_1473200	125	9.070	1.251	2.755	UR

The sequences of the selected transcripts were identified using the gene data of P. falciparum 3D7 strain (PF3D7), which was retrieved from PlasmoDB as a genomic database of P. falciparum and GenDB of the National Center for Biotechnology Information.

The expression levels of the transcripts of P. falciparum treated with DHA (Pf-DHA), BNTX (Pf-BNTX), or RIMO (Pf-RIMO) were quantitatively calculated on the basis of control data obtained from P. falciparum grown in medium only (Pf-cont). DR: downregulation, UR: upregulation, ALG14: UDP-N-acetylglucosamine transferase subunit ALG14, GLO1: glyoxalase I, tGLO2: targeted glyoxalase II, PHISTc: Plasmodium helical interspersed subtelomeric protein c, GDPD: glycerophosphodiester phosphodiesterase, QCR8: Cytochrome b-c1 complex subunit 8, BCKDHA: mitochondrial 2-oxoisovalerate dehydrogenase subunit alpha, KH: KH domain-containing protein, ZFP: zinc finger protein, S/T PK: serine/threonine protein kinase, MFSP: major facilitator superfamily domain-containing protein, ZIP1: zinc transporter ZIP1, ZIPCO: ZIP domain-containing protein, CDF: cation diffusion facilitator family protein, PfEMP1: P. falciparum erythrocyte membrane protein 1, IMP2: immune mapped protein 1-like protein, and UF: unknown function.