Table 4.
Factors associated with mortality in melioidosis patients (n=70)
| Variables | Nonsurvivors (35%), n (%) | Survivors (35%), n (%) | Unadjusted | Adjusted | ||
|---|---|---|---|---|---|---|
|
|
|
|||||
| HR (95% CI) | P | HR (95% CI) | P | |||
| Age | ||||||
| ≥50 (32) | 16 (50.0) | 16 (50.0) | 0.92 (0.47–1.78) | 0.80 | - | - |
| <50 (38) | 19 (50.0) | 19 (50.0) | 1 | |||
| Sex | ||||||
| Male (63) | 31 (49.2) | 32 (50.8) | 0.87 (0.31–2.45) | 0.79 | - | - |
| Female (7) | 4 (57.1) | 3 (42.9) | 1 | |||
| Diabetes | ||||||
| Yes (55) | 28 (50.9) | 27 (49.1) | 1.24 (0.54–2.84) | 0.61 | - | - |
| No (15) | 7 (46.7) | 8 (53.3) | 1 | |||
| CKD | ||||||
| Yes (9) | 8 (88.9) | 1 (11.1) | 2.14 (0.97–4.73) | 0.06 | - | - |
| No (61) | 27 (44.3) | 34 (55.7) | 1 | |||
| Alcoholism | ||||||
| Yes (43) | 23 (53.5) | 20 (46.5) | 1.27 (0.63–2.56) | 0.50 | - | - |
| No (27) | 12 (44.4) | 15 (55.6) | 1 | |||
| Occupational exposure | ||||||
| Yes (55) | 30 (54.5) | 25 (45.5) | 1.96 (0.76–5.06) | 0.16 | - | - |
| No (15) | 5 (33.3) | 10 (66.7) | 1 | |||
| Risk factors† | ||||||
| Present | 32 (49.2) | 33 (50.8) | 0.81 (0.25–2.64) | 0.72 | - | - |
| Absent | 3 (60.0) | 2 (40.0) | 1 | |||
| Bacteremia | ||||||
| Yes (47) | 32 (68.1) | 15 (31.9) | 7.89 (2.41–25.87) | 0.001 | 3.62 (0.96–13.72) | 0.06 |
| No (23) | 3 (13.0) | 20 (87.0) | 1 | |||
| Sepsis | ||||||
| Yes (33) | 27 (81.8) | 6 (18.2) | 6.19 (2.79–13.73) | <0.001 | 3.50 (1.44–8.54) | 0.01 |
| No (37) | 8 (21.6) | 29 (78.4) | 1 | |||
| Presentation | ||||||
| Acute (65) | 31 (47.7) | 34 (52.3) | 0.60 (0.21–1.69) | 0.33 | - | - |
| Chronic(5) | 4 (80.0) | 1 (20.0) | 1 | |||
†Presence of any one risk factor. HR: Hazard ratio, CI: Confidence interval, CKD: Chronic kidney disease