Table 3.

Linear associations between PSA level and mtDNA copy number

		Quartile 2 vs Quartile 1			Quartile 3 vs Quartile 1			Quartile 4 vs Quartile 1			continuous mtDNA CN
Among Controls	n	Beta	SE	P	Beta	SE	P	Beta	SE	P	Beta	SE	P
PSA level at draw	790	0.11	0.08	0.177	0.14	0.08	0.088	0.18	0.09	0.039	0.17	0.07	0.014
Among All Cases
PSA level at draw	793	0.02	0.06	0.720	0.08	0.06	0.223	0.07	0.06	0.276	0.08	0.06	0.239
PSA level at diagnosis	745	−0.03	0.07	0.683	0.02	0.08	0.786	−0.06	0.07	0.439	−0.05	0.07	0.507
Among Aggressive Cases
PSA level at draw	117	−0.17	0.18	0.347	0.03	0.18	0.878	0.21	0.19	0.273	0.10	0.21	0.635
PSA level at diagnosis	103	−0.37	0.34	0.284	−0.50	0.33	0.134	−0.20	0.31	0.519	−0.32	0.33	0.332
Among Non-Aggressive Cases
PSA level at draw	666	0.06	0.06	0.315	0.11	0.06	0.069	0.07	0.07	0.272	0.06	0.05	0.247
PSA level at diagnosis	636	−0.03	0.07	0.635	0.06	0.07	0.374	−0.05	0.07	0.460	−0.06	0.06	0.358

Both PSA and mitochondrial DNA copy number natural log-transformed.

Among controls, adjusted for age at mtDNA copy number blood draw and cigarette smoking.

Among cases, adjusted for age at mtDNA copy number blood draw, days from draw to diagnosis, and cigarette smoking.

Aggressive cases models excluded one individual as an influential point