Table 4.

Analyses of PCa risk and mtDNA copy number with cases stratified by PSA level at diagnosis.

	Quartile 1	Quartile 2		Quartile 3		Quartile 4		Continuous
mtDNA copy number range	< 70	70 – 92		93 – 113		> 113
Overall	Ref	OR (95% CI)	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value	OR	95% CI	p-value
High PSA at diagnosis (≥ 4.0)	1.0	1.16 (0.86–1.57)	0.318	1.12 (0.83–1.52)	0.459	1.25 (0.93–1.68)	0.144	1.26	0.98–1.63	0.068
Low PSA at diagnosis (< 4.0)	1.0	1.09 (0.66–1.79)	0.734	0.80 (0.46–1.39)	0.424	1.15 (0.70–1.88)	0.586	1.11	0.73–1.67	0.632
Non-Aggressive Pca
High PSA at diagnosis (≥ 4.0)	1.0	1.07 (0.78–1.46)	0.692	1.07 (0.78–1.48)	0.672	1.27 (0.94–1.73)	0.121	1.32	1.02–1.72	0.037
Low PSA at diagnosis (< 4.0)	1.0	1.04 (0.60–1.79)	0.892	0.87 (0.48–1.57)	0.64	1.17 (0.68–2.00)	0.573	1.16	0.74–1.81	0.527
Aggressive Pca
High PSA at diagnosis (≥ 4.0)	1.0	1.85 (0.99–3.44)	0.053	1.26 (0.65–2.45)	0.487	1.07 (0.54–2.10)	0.845	0.93	0.55–1.58	0.787
Low PSA at diagnosis (< 4.0)	1.0	1.51 (0.48–4.72)	0.476	0.67 (0.13–2.42)	0.444	1.08 (0.32–3.60)	0.903	1.18	0.42–3.37	0.752

mtDNA copy number natural log-transformed.

Adjusted for age at diagnosis and year of blood draw.

All controls included in each analysis