Table 1.
Study participant characteristics, stratified by race.
| Caucasians | African-Americans | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Controls (n=942) | Cases (n=932) | Controls (n=302) | Cases (n=154) | ||||||
| IL-16 concentration, ng/mL (mean, sd)* | 133.8 | 179.2 | 134.7 | 110.6 | 111.7 | 83.5 | 95.2 | 61.3 | |
| Age (n, %) | ≤ 59 | 196 | 20.8 | 166 | 17.8 | 74 | 24.5 | 39 | 24.8 |
| 60-64 | 283 | 30.0 | 319 | 34.2 | 103 | 34.1 | 51 | 32.1 | |
| 65-69 | 284 | 30.2 | 287 | 30.8 | 74 | 24.5 | 37 | 24.0 | |
| ≥ 70 | 179 | 19.0 | 160 | 17.2 | 51 | 16.9 | 27 | 17.5 | |
| Year of Randomization (n, %) | 1994-1995 | 333 | 35.4 | 384 | 41.2 | 102 | 33.8 | 51 | 33.1 |
| 1996-1998 | 480 | 51.0 | 446 | 47.9 | 128 | 42.4 | 66 | 42.9 | |
| 1999-2001 | 129 | 13.7 | 102 | 11.0 | 72 | 23.8 | 37 | 24.0 | |
| Age at Baseline Draw (mean, sd) | 64.3 | 5.2 | 64.4 | 5.0 | 63.7 | 5.3 | 63.4 | 5.4 | |
| Age at Diagnosis/Selection (mean, sd) | 68.2 | 5.6 | 68.4 | 5.6 | 68.0 | 5.6 | 68.4 | 5.6 | |
| Family History of PCa (n, %)** | No | 876 | 93.7 | 809 | 87.4 | 259 | 86.6 | 132 | 85.7 |
| Yes | 52 | 5.6 | 103 | 11.1 | 32 | 10.7 | 14 | 9.0 | |
| Unknown | 7 | 0.8 | 14 | 1.5 | 8 | 2.7 | 8 | 5.2 | |
| BMI at Baseline, kg/m2 (mean, sd) | 27.7 | 4.1 | 27.4 | 3.6 | 27.9 | 4.6 | 27.7 | 4.2 | |
| missing (n) | 10 | 13 | 4 | 1 | |||||
| Cigarette Smoking (n, %)*** | Never | 354 | 37.6 | 412 | 44.2 | 82 | 27.2 | 51 | 33.1 |
| Former | 107 | 11.4 | 68 | 7.3 | 76 | 25.3 | 27 | 17.5 | |
| Current | 481 | 51.1 | 452 | 48.5 | 143 | 47.5 | 76 | 49.4 | |
| missing (n) | 1 | ||||||||
| Aspirin Use | No | 417 | 44.3 | 455 | 48.8 | 154 | 51.0 | 92 | 60.1 |
| Yes | 524 | 55.7 | 477 | 51.2 | 148 | 49.0 | 61 | 39.9 | |
| missing (n) | 1 | 1 | |||||||
| Ibuprofen Use | No | 713 | 75.8 | 705 | 75.8 | 214 | 71.3 | 120 | 78.4 |
| Yes | 228 | 24.2 | 225 | 24.2 | 86 | 28.7 | 33 | 21.6 | |
| missing (n) | 1 | 2 | 2 | 1 | |||||
| Gonorrhea | No | 892 | 95.8 | 890 | 95.9 | 201 | 70.0 | 102 | 69.9 |
| Yes | 39 | 4.2 | 38 | 4.1 | 86 | 30.0 | 44 | 30.1 | |
| missing (n) | 11 | 4 | 15 | 8 | |||||
| Syphilis | No | 931 | 99.2 | 924 | 99.7 | 258 | 93.8 | 136 | 93.8 |
| Yes | 8 | 0.9 | 3 | 0.3 | 17 | 6.2 | 9 | 6.2 | |
| missing (n) | 3 | 5 | 27 | 9 | |||||
| Gleason Score (n, %) | ≤ 6 | 412 | 44.2 | 87 | 56.5 | ||||
| 7 | 363 | 38.9 | 43 | 28.1 | |||||
| ≥ 8 | 147 | 15.8 | 21 | 13.6 | |||||
| Unknown | 10 | 1.1 | 3 | 1.3 | |||||
| PCa Stage (n, %) | I/II | 731 | 78.4 | 139 | 90.3 | ||||
| III/IV | 201 | 21.6 | 15 | 9.7 | |||||
| Aggressive PCa (Gleason Score ≥8 or Stage III/IV) (n, %) | No | 638 | 68.5 | 123 | 79.9 | ||||
| Yes | 292 | 31.3 | 30 | 19.5 | |||||
| Unclassifiable | 2 | 0.2 | 1 | 0.6 | |||||
*
p for IL-16 African-Americans 0.0454
**
p for Family History of PCa Caucasians < 0.001
***
p for cigarette smoking history Caucasians 0.001