. Author manuscript; available in PMC: 2023 Jul 18.

Published in final edited form as: Cancer Causes Control. 2018 Mar 28;29(4-5):455–464. doi: 10.1007/s10552-018-1012-5

Table 4.

Effect modification of association between IL-16 and PCa, by self-reported history of gonorrhea.

	Tertile 1				Tertile 2 vs Tertile 1				Tertile 3 vs Tertile 1				Continuous ln(IL-16)
Caucasians	no. cases/no. controls	OR	95% CI	p-value	no. cases/no. controls	OR	95% CI	p-value	no. cases/no. controls	OR	95% CI	p-value	no. cases/no. controls	OR	95% CI	p-value	p_interaction
No history of gonorrhea	282/283	1.0	reference		294/311	0.96	0.76-1.22	0.76	314/298	1.06	0.83-1.34	0.65	890/892	1.04	0.91-1.17	0.59
Positive history of gonorrhea	10/21	1.0	reference		13/10	2.72	0.86-8.50	0.09	15/8	3.64	1.14-11.6	0.03	38/39	2.64	1.16-6.04	0.02	0.019
African-Americans
No history of gonorrhea	43/64	1.0	reference		29/72	0.53	0.28-1.01	0.05	30/65	0.74	0.39-1.40	0.35	102/201	0.91	0.66-1.25	0.54
Positive history of gonorrhea	18/26	1.0	reference		14/29	0.63	0.25-1.64	0.35	12/31	0.72	0.27-1.89	0.50	44/86	0.64	0.37-1.11	0.11	0.27

All models adjusted for study center, use of thawed aliquot (yes/no), time in study, age and year at randomization.